眼眶鼻型自然杀伤/ T细胞淋巴瘤的急性表现

Acute presentation of nasal-type natural killer/T-cell lymphoma of the orbit.

作者信息

Qin Wei, Yin Zhengqin, Madge Simon N

机构信息

Southwest Eye Hospital/Southwest Hospital, Third Military Medical University, Chongqing - China.

出版信息

Eur J Ophthalmol. 2009 Jul-Aug;19(4):679-82. doi: 10.1177/112067210901900425.

DOI:10.1177/112067210901900425

PMID:19551687

Abstract

PURPOSE

An unusual case of nasal-type natural killer/T-cell lymphoma (NKTL) of the orbit is reported.

METHODS

The clinical history, computed tomography, magnetic resonance imaging, and biopsy specimen of a 29-year-old man with a right orbital lymphoma were evaluated.

RESULTS

The patient initially presented with conjunctival injection and had flu-like symptoms before developing right proptosis and reduced vision; imaging showed a diffuse infiltrative process throughout the orbit. Orbital biopsy revealed angiodestruction with prominent necrosis, and angiocentric lymphoma growth and lymphoma cells were positively stained for CD3, CD20, CD45RO, CD56, cytotoxic molecules (granzyme B and T-cell intracellular antigen-1), and Epstein-Barr virus.

CONCLUSIONS

NKTL is rare and may present acutely; the imaging findings presented serve to highlight the radiologic features of the disease.

摘要

目的

报告1例罕见的眼眶鼻型自然杀伤/T细胞淋巴瘤（NKTL）病例。

方法

对1例患有右眼眶淋巴瘤的29岁男性患者的临床病史、计算机断层扫描、磁共振成像和活检标本进行评估。

结果

患者最初表现为结膜充血，在出现右眼球突出和视力下降之前有类似流感的症状；影像学检查显示整个眼眶有弥漫性浸润性病变。眼眶活检显示血管破坏并伴有显著坏死，血管中心性淋巴瘤生长，淋巴瘤细胞对CD3、CD20、CD45RO、CD56、细胞毒性分子（颗粒酶B和T细胞细胞内抗原-1）以及爱泼斯坦-巴尔病毒呈阳性染色。