Fu Zhi-fang, Liu Mei-lin
Department of Geriatrics, First Hospital of Peking University, Beijing 100034, China.
Zhonghua Yi Xue Za Zhi. 2009 Feb 3;89(4):260-2.
To investigate the postprandial changes of blood lipid after ordinary Chinese diet and the influencing factors thereof.
Peripheral venous blood samples were collected from 88 patients, 72 males and 16 females, aged (65 +/- 12), 53 with hypertension, 35 with coronary heart diseases, and 27 with diabetes, while fasting and 4 h after breakfast and lunch to measure the levels of lipoproteins, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoA), ApoB, lipoprotein (Lp) (a), oxidized LDL (ox-LDL). Homeostasis model assessment insulin resistance index (HOMA-IR) was calculated. Weight, height, waist circumference, and hip circumference were examined, and body mass index (BMI) and waist/hip ratio (WHR) were calculated.
The TG level after breakfast was (2.79 +/- 0.19) mmol/L, significantly higher than the fasting level by 49.5% [(1.94 +/- 0.13) mmol/L, P < 0.05]. The TG level after lunch was (3.08 +/- 0.26) mmol/L, significantly higher than the fasting level by 58.8% [(1.94 +/- 0.13) mmol/L, P < 0.05]. The ox-LDL after breakfast was (430 +/- 21) microg/L, significantly higher than the fasting level by 32.6% [(324 +/- 14) microg/L, P < 0.05] and the ox-LDL level after lunch was (448 +/- 17) microg/L, significantly higher than the fasting level by 38.1% [(324 +/- 14) microg/L, P < 0.05]. The fasting insulin level was (62 +/- 4) pmol/L, and the HOMA-IR was (15.27 +/- 1.08). The fasting insulin level was positively correlated with the fasting and postprandial TG levels (all P < 0.01). The IR index was positively correlated with the fasting TG and TG after breakfast (both P < 0.05). Fasting insulin and HOMA-IR were negatively correlated with the fasting and postprandial HDL-C levels (all P < 0.05), and positively correlated with the fasting and postprandial TC/HDL-C levels (all P < 0.05). BMI and WHR were negatively correlated with the fasting and postprandial HDL-C (both P < 0.01). BMI was positively correlated with fasting and postprandial TG (both P < 0.05). The insulin level, HOMA-IR, and BMI were negatively correlated with LPL (r = -0.232 - 0.297, P < 0.05). LPL were positively correlated with fasting and postprandial HDL-C levels (r = 0.37, 0.31, 0.35, all P < 0.01).
The TG and ox-LDL levels significantly increased postprandially. The postprandial blood lipid levels are significantly correlated with the fasting blood lipids.
探讨普通中餐饮食后血脂的餐后变化及其影响因素。
收集88例患者（男性72例，女性16例，年龄(65±12)岁）的外周静脉血样本，其中53例患有高血压，35例患有冠心病，27例患有糖尿病，分别在空腹、早餐后4小时和午餐后4小时测量脂蛋白水平，包括总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(ApoA)、ApoB、脂蛋白(a)[Lp(a)]、氧化型低密度脂蛋白(ox-LDL)。计算稳态模型评估胰岛素抵抗指数(HOMA-IR)。测量体重、身高、腰围和臀围，并计算体重指数(BMI)和腰臀比(WHR)。
早餐后TG水平为(2.79±0.19)mmol/L，显著高于空腹水平49.5%[(1.94±0.13)mmol/L，P<0.05]。午餐后TG水平为(3.08±0.26)mmol/L，显著高于空腹水平58.8%[(1.94±0.13)mmol/L，P<0.05]。早餐后ox-LDL为(430±21)μg/L，显著高于空腹水平32.6%[(324±14)μg/L，P<0.05]，午餐后ox-LDL水平为(448±17)μg/L，显著高于空腹水平38.1%[(324±14)μg/L，P<0.05]。空腹胰岛素水平为(62±4)pmol/L，HOMA-IR为(15.27±1.08)。空腹胰岛素水平与空腹及餐后TG水平呈正相关（均P<0.01）。IR指数与空腹TG及早餐后TG呈正相关（均P<0.05）。空腹胰岛素和HOMA-IR与空腹及餐后HDL-C水平呈负相关（均P<0.05），与空腹及餐后TC/HDL-C水平呈正相关（均P<0.05）。BMI和WHR与空腹及餐后HDL-C呈负相关（均P<0.01）。BMI与空腹及餐后TG呈正相关（均P<0.05）。胰岛素水平、HOMA-IR和BMI与脂蛋白脂肪酶(LPL)呈负相关(r=-0.232～-0.297，P<0.05)。LPL与空腹及餐后HDL-C水平呈正相关(r=0.37、0.31、0.35，均P<0.01)。
餐后TG和ox-LDL水平显著升高。餐后血脂水平与空腹血脂显著相关。
