Salces I, Rebato E, Susanne C, Hauspie R C, Saha R, Fernández-López J R, Dasgupta P
Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country, 48080 Bilbao, Spain.
Homo. 2009;60(4):373-88. doi: 10.1016/j.jchb.2009.03.003. Epub 2009 Jun 23.
The aim of the present study was to examine the heritability of 11 traits in a mixed-longitudinal sample of Indian siblings, and to determine whether heritability estimates vary during the growth period and whether they are influenced by sex. The sample consisted of 245 brothers and 213 sisters from 138 nuclear families living in a semi-urban area in Kolkata, India. The age ranged between 5 and 19 years. The traits were standardised for age and sex using standard deviation scores (SDS) produced by the LMS method (Cole, T.J., 1988. Fitting smoothed centile curves to reference data. J. R. Stat. Soc. A 151, 385-418). The standard deviation scores were analysed by PCA. The two factors with eigenvalues above 1 explained 77.3% of the variance; they showed a high level of pleiotropism present among the studied traits and represented body lengths (PC1) and body weight and breadths (PC2). The heritability between all types of siblings (irrespective of sex) for the PC1 and PC2 was estimated. The heritability between various pairs of siblings showed variations along the whole ontogenetic period studied. During the childhood and pre-pubertal period, heritability between brothers, brother-sister pairs and any sibling pairs was mostly constant, with small and non-significant variations. All the pairs showed the lowest degree of heritability during puberty for PC1 but not for PC2, with significant changes of heritability estimates between adolescence and adulthood, in most of the analysed sibling pairs and in both PC factors. The highest heritability was generally observed at the end of the examined growth period in all pairs. A significant effect of sex on heritability was only detected for PC2 at 11 years of age.
本研究的目的是检验印度同胞混合纵向样本中11个性状的遗传力，并确定遗传力估计值在生长期间是否会发生变化，以及它们是否受性别影响。样本包括来自印度加尔各答一个半城市地区的138个核心家庭的245名兄弟和213名姐妹。年龄在5至19岁之间。使用LMS方法（Cole, T.J., 1988. Fitting smoothed centile curves to reference data. J. R. Stat. Soc. A 151, 385 - 418）产生的标准差分数（SDS）对性状进行年龄和性别标准化。通过主成分分析（PCA）对标准差分数进行分析。特征值大于1的两个因子解释了77.3%的方差；它们显示出所研究性状之间存在高度的多效性，代表身体长度（PC1）和体重及宽度（PC2）。估计了PC1和PC2在所有类型同胞（不分性别）之间的遗传力。不同同胞对之间的遗传力在所研究的整个个体发育时期呈现出变化。在儿童期和青春期前，兄弟之间、兄妹对以及任何同胞对之间的遗传力大多保持不变，变化较小且不显著。对于PC1，所有同胞对在青春期的遗传力最低，但对于PC2并非如此，在大多数分析的同胞对以及两个PC因子中，青春期和成年期之间遗传力估计值有显著变化。在所有同胞对中，通常在检查的生长期末期观察到最高的遗传力。仅在11岁时检测到性别对PC2遗传力有显著影响。
