Maruno H, Shimizu T, Kawai K, Hirohata K
Department of Orthopaedic Surgery, Kobe University School of Medicine, Japan.
J Bone Joint Surg Br. 1991 Nov;73(6):911-5. doi: 10.1302/0301-620X.73B6.1955435.
We studied the effect of a lipid clearing agent (clinofibrate) on the osteocytes of rabbits treated with corticosteroids. Thirty-one rabbits were divided into four groups: (A) steroid-treated with a normal diet, (B) steroid-treated and one a diet with added clinofibrate, (C) non-steroid-treated, on a diet with clinofibrate; and (D) non-steroid-treated on a normal diet. All the steroid-treated animals demonstrated hyperlipidaemia and fatty degeneration of the liver. Lipid-containing osteocytes were seen in the femoral heads of these animals. However, those which received clinofibrate (group B) had less severe lipidaemia, and less severe degeneration of the liver. In them, only the osteocytes around the haversian canals exhibited lipid inclusions. Clinofibrate appears to modify lipid metabolism, diminishing the steroid induced accumulation of lipids within osteocytes. This effect may protect against steroid-mediated osteonecrosis.
我们研究了一种脂质清除剂（氯贝丁酯）对接受皮质类固醇治疗的兔子骨细胞的影响。31只兔子被分为四组：（A）接受类固醇治疗且饮食正常；（B）接受类固醇治疗且饮食中添加氯贝丁酯；（C）未接受类固醇治疗，饮食中含有氯贝丁酯；（D）未接受类固醇治疗且饮食正常。所有接受类固醇治疗的动物均出现高脂血症和肝脏脂肪变性。在这些动物的股骨头中可见含脂质的骨细胞。然而，接受氯贝丁酯治疗的动物（B组）血脂血症较轻，肝脏变性也较轻。在它们当中，只有哈弗斯管周围的骨细胞出现脂质包涵体。氯贝丁酯似乎可以改变脂质代谢，减少类固醇诱导的脂质在骨细胞内的蓄积。这种作用可能预防类固醇介导的骨坏死。
