副神经节瘤的临床病理分析及文献复习
Clinicopathological analysis of paraganglioma with literature review.
作者信息
Feng Ning, Zhang Wen-Yan, Wu Xiao-Ting
机构信息
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
出版信息
World J Gastroenterol. 2009 Jun 28;15(24):3003-8. doi: 10.3748/wjg.15.3003.
AIM
To investigate the 152 cases of paragangliomas resected over the past 32 years in West China Hospital clinicopathologically.
METHODS
All cases of paragangliomas diagnosed at the Department of Gastrointestinal Surgery and Department of Pathology, West China Hospital, China were reviewed. The pathological documents were supplied by the Department of Pathology, West China Hospital, and other necessary data were extracted from the hospital records. The statistical analyses were performed by survival analysis (Kaplan-Meier method), descriptive statistical analyses and chi(2) analysis.
RESULTS
The neuroendocrine marker vimentin was found to be selectively expressed in the benign tumors, and there were significant differences in the expression of those markers in both benign and malignant tumors. The survival analysis revealed that survival correlated significantly with the malignancy, metastasis and nodal status.
CONCLUSION
Vimentin may be useful in the differential diagnosis between malignant and benign tumors. The difference in the expression of this marker in the tumors could be a clue to the future clinical diagnosis. The malignancy, metastasis and the nodal status may predict the prognosis of this disease.
目的
对过去32年在中国西部医院手术切除的152例副神经节瘤进行临床病理研究。
方法
回顾性分析在中国西部医院胃肠外科和病理科诊断的所有副神经节瘤病例。病理资料由中国西部医院病理科提供，其他必要数据从医院病历中提取。采用生存分析（Kaplan-Meier法）、描述性统计分析和卡方分析进行统计学分析。
结果
发现神经内分泌标志物波形蛋白在良性肿瘤中选择性表达，这些标志物在良性和恶性肿瘤中的表达存在显著差异。生存分析显示，生存与恶性程度、转移和淋巴结状态显著相关。
结论
波形蛋白可能有助于良恶性肿瘤的鉴别诊断。该标志物在肿瘤中的表达差异可能为未来临床诊断提供线索。恶性程度、转移和淋巴结状态可能预测该病的预后。
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