Rosen Jeffrey M, Jordan Craig T
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Science. 2009 Jun 26;324(5935):1670-3. doi: 10.1126/science.1171837.
The investigation and study of cancer stem cells (CSCs) have received enormous attention over the past 5 to 10 years but remain topics of considerable controversy. Opinions about the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of CSCs to cancer therapy differ widely. In the following commentary, we discuss the nature of the debate, the parameters by which CSCs can or cannot be defined, and the identification of new potential therapeutic targets elucidated by considering cancer as a problem in stem cell biology.
在过去5到10年里，癌症干细胞（CSCs）的调查研究受到了极大关注，但仍然是颇具争议的话题。关于CSC假说的有效性、CSCs的生物学特性以及CSCs与癌症治疗的相关性，各方观点差异很大。在以下评论中，我们将讨论这场争论的本质、界定CSCs的参数，以及通过将癌症视为干细胞生物学问题而阐明的新潜在治疗靶点的识别。
