Lama Javier R, Lucchetti Aldo, Cabezas Cesar, Suarez-Ognio Luis, Sanchez Jorge
Investigaciones Medicas en Salud (INMENSA), Lima, Peru.
Am J Trop Med Hyg. 2009 Jul;81(1):184-6.
Hepatitis C virus (HCV) infection occurs among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) because of shared routes of transmission. To assess the association between HCV and HIV infection among MSM in Peru, we conducted a matched case-control study (162 HIV-positive cases and 324 HIV-negative controls) among participants of an HIV sentinel surveillance survey in six urban cities. The HCV infection was initially screened using anti-HCV ELISA and immunoblot assay, and thereafter confirmed by the HCV RNA qualitative assay. Among cases, no confirmed HCV infection was found while among controls, only two confirmed HCV infections were reported (0.62%). This matched case-control reports a very low probability of association between HCV and HIV co-infection and suggests a very low prevalence of HCV infection among MSM in Peru.
由于传播途径相同,丙型肝炎病毒(HCV)感染在感染人类免疫缺陷病毒(HIV)的男男性行为者(MSM)中出现。为评估秘鲁男男性行为者中HCV与HIV感染之间的关联,我们在六个城市的HIV哨点监测调查参与者中开展了一项匹配病例对照研究(162例HIV阳性病例和324例HIV阴性对照)。HCV感染最初采用抗-HCV ELISA和免疫印迹法进行筛查,随后通过HCV RNA定性检测进行确认。在病例组中,未发现确诊的HCV感染,而在对照组中,仅报告了两例确诊的HCV感染(0.62%)。这项匹配病例对照研究报告称,HCV与HIV合并感染之间关联的可能性非常低,提示秘鲁男男性行为者中HCV感染率非常低。