额颞叶痴呆家族中抑郁症的发生：一项家族史研究。
Occurrence of depression in families with frontotemporal dementia: a family history study.
作者信息
Horstmann V, Gräsbeck A
机构信息
Department of Health Sciences, Lund University, Lund, Sweden.
出版信息
Neuroepidemiology. 2009;33(2):124-30. doi: 10.1159/000226125. Epub 2009 Jun 26.
BACKGROUND
There are clinical similarities between frontotemporal dementia (FTD) and depression. The aim is to study co-aggregation of depression in families with FTD, indicating the existence of common aetiological factors.
METHODS
The study included 74 index patients with FTD and their 540 first-degree relatives above the age of 15 years. Occurrence of depression was studied at 3 different levels.
RESULTS
The incidence of depression in first-degree relatives of FTD patients was not higher than that of a general population. Occurrence of depression was not higher in families where parents had FTD compared to families with parents having no indications of FTD. Individuals with FTD had not suffered from depression to a greater extent than those without FTD.
CONCLUSIONS
The hypothesis of a common aetiological factor of FTD and depression was not supported.
背景
额颞叶痴呆（FTD）与抑郁症在临床上存在相似之处。目的是研究FTD家族中抑郁症的共聚集情况，以表明存在共同的病因因素。
方法
该研究纳入了74例FTD索引患者及其540名15岁以上的一级亲属。在3个不同层面研究了抑郁症的发生情况。
结果
FTD患者一级亲属中抑郁症的发病率并不高于普通人群。与父母无FTD迹象的家庭相比，父母患有FTD的家庭中抑郁症的发生率并不更高。患有FTD的个体并不比未患有FTD的个体患抑郁症的程度更严重。
结论
FTD与抑郁症存在共同病因因素的假设未得到支持。
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