Bao Philip, Bartlett David
Division of Surgical Oncology, University of Pittsburgh Medical Center, Cancer Pavilion 414, 5150 Centre Avenue, Pittsburgh, PA 15232, USA.
Cancer J. 2009 May-Jun;15(3):204-11. doi: 10.1097/PPO.0b013e3181a9c6f0.
Peritoneal surface malignancies may now be approached with curative intent using a strategy of cytoreductive surgery combined with intraperitoneal chemotherapy. Complete cytoreduction to tumor nodules less than 2.5 mm is considered critical to the efficacy of the local chemotherapy and achieving complete cytoreduction impacts long-term survival. However, this procedure results in significant morbidity with frequent surgical complications. Meticulous technique must be used to limit anastomotic complications, operative time, and blood loss. This review summarizes the major issues surrounding visceral resection and peritonectomy during cytoreductive surgery. Problem areas, which merit special attention, are described, and recommendations are made with regard to surgical technique.
如今,对于腹膜表面恶性肿瘤,可以采用细胞减灭术联合腹腔内化疗的策略进行根治性治疗。将肿瘤结节完全减灭至小于2.5毫米被认为对局部化疗的疗效至关重要,实现完全细胞减灭对长期生存有影响。然而,该手术会导致显著的发病率,手术并发症频繁。必须采用精细的技术来限制吻合口并发症、手术时间和失血。本综述总结了细胞减灭术中内脏切除和腹膜切除术的主要问题。描述了值得特别关注的问题领域,并就手术技术提出了建议。