Zhang Wei Sen, Jiang Chao Qiang, Cheng Kar Keung, Adab Peymane, Thomas G Neil, Liu Bin, Lam Kin-Bong Hubert, Schooling C Mary, Lam Tai Hing
Guangzhou Number 12 Hospital, Guangzhou, Guangdong, China.
Hypertens Res. 2009 Sep;32(9):741-7. doi: 10.1038/hr.2009.92. Epub 2009 Jun 26.
Although the J-shaped association between alcohol consumption and blood pressure (BP) is well known, the effect of alcohol sensitivity on this relationship is less clear. We studied the association of alcohol sensitivity and alcohol use with BP and hypertension. This cross-sectional analysis included 19 335 older participants from the Guangzhou Biobank Cohort Study recruited from 2003 to 2006, using clinically measured BP and self-reported alcohol use and alcohol sensitivity. Alcohol use was rare in women, in whom light-to-moderate drinkers (<140 g ethanol per week) without alcohol sensitivity had lower systolic and diastolic BPs (mean difference 5.3 (95% CI 3.8-6.9) mm Hg and 1.9 (1.1-2.7) mm Hg, respectively) and a reduced risk of hypertension (0.62 (0.53-0.72)) relative to never drinkers. Similarly, excessive drinkers (>or=140 g ethanol per week) without alcohol sensitivity had a significantly higher systolic and diastolic BP and risk of hypertension than did nondrinkers (mean difference 5.1 (2.8-7.4) mm Hg, 2.7 (1.5-4.0) mm Hg and 34% (8-66%), respectively, for men). These differences were even greater for men with alcohol sensitivity (mean differences 12.0 (8.9-15.2) mm Hg, 6.2 (4.5-7.9) mm Hg and 95% CI (46-159%), respectively). Alcohol sensitivity and alcohol use were both associated with elevated BP and risk of hypertension in an older Chinese population. Alcohol sensitivity may aggravate the effect of drinking on BP. Limiting alcohol use to two drinks per day for men and one drink a day for women may be suitable for East Asians. Reduction of alcohol consumption should be an important public health target.
尽管饮酒与血压（BP）之间的J形关联已广为人知，但酒精敏感性对这种关系的影响尚不清楚。我们研究了酒精敏感性和饮酒与血压及高血压之间的关联。这项横断面分析纳入了2003年至2006年从广州生物样本库队列研究中招募的19335名老年参与者，采用临床测量的血压、自我报告的饮酒情况和酒精敏感性。女性饮酒情况罕见，在无酒精敏感性的轻度至中度饮酒者（每周<140克乙醇）中，其收缩压和舒张压较低（平均差异分别为5.3（95%CI 3.8 - 6.9）毫米汞柱和1.9（1.1 - 2.7）毫米汞柱），与从不饮酒者相比，高血压风险降低（0.62（0.53 - 0.72））。同样，无酒精敏感性的过量饮酒者（每周≥140克乙醇）的收缩压和舒张压显著高于不饮酒者，高血压风险也更高（男性的平均差异分别为5.1（2.8 - 7.4）毫米汞柱、2.7（1.5 - 4.0）毫米汞柱和34%（8 - 66%））。对于有酒精敏感性的男性，这些差异更大（平均差异分别为12.0（8.9 - 15.2）毫米汞柱、6.2（4.5 - 7.9）毫米汞柱和95%CI（46 - 159%））。在老年中国人群中，酒精敏感性和饮酒均与血压升高及高血压风险相关。酒精敏感性可能会加剧饮酒对血压的影响。男性每天饮酒限制在两杯、女性每天一杯可能适合东亚人。减少酒精消费应成为一项重要的公共卫生目标。
