Li Yan, Wang Ji-Guang, Gao Ping-Jin, Wang Gu-Liang, Qian Yue-Sheng, Zhu Ding-Liang, Staessen Jan A
Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Second Medical University, Shanghai, China.
Am J Hypertens. 2006 May;19(5):448-53. doi: 10.1016/j.amjhyper.2005.08.014.
Blood pressure (BP) increases with body mass index (BMI) and excessive alcohol intake. Few epidemiologic studies explored the interaction between BMI and alcohol intake in relation to BP.
We randomly selected 10 villages with a mixed population of HAN and SHE Chinese in the JingNing County in Southeast China. We measured BP, anthropometric characteristics, and alcohol intake in 1688 participants. Our statistical methods included single and multiple linear and logistic regressions.
HAN (n = 520) and SHE (n = 1168) had a similar sex and age distribution. SHE Chinese, compared with HAN, had a higher BP (128.0/79.7 v 121.5/76.9 mm Hg, P < .001), and more frequently reported alcohol intake (45.0% v 27.7%; P < .001), but showed lower BMI (22.2 v 22.5 kg/m2; P = .05) and waist-to-hip ratio (0.83 v 0.87; P < .001). In SHE, but not HAN, there was a significant interaction (P < .01) between BMI and alcohol intake in relation to BP. In SHE with BMI < 25 kg/m2, BP was significantly higher in drinkers than nondrinkers (129.4/80.2 v 124.2/77.4 mm Hg, P < .001), whereas among SHE with BMI > or = 25 kg/m2, BP was not associated with alcohol intake (134.3/84.9 v 136.8/85.7 mm Hg, P > .41). Accordingly, in SHE Chinese, the slope of BP associated with BMI was less steep (P < .01) in drinkers than nondrinkers.
Among SHE Chinese, alcohol intake and BMI interactively influenced BP. Further research is required to elucidate the underlying mechanism.
血压（BP）随体重指数（BMI）和过量饮酒而升高。很少有流行病学研究探讨BMI与饮酒量之间关于血压的相互作用。
我们在中国东南部景宁县随机选择了10个有汉族和畲族混合人口的村庄。我们测量了1688名参与者的血压、人体测量特征和饮酒量。我们的统计方法包括单因素和多因素线性及逻辑回归。
汉族（n = 520）和畲族（n = 1168）的性别和年龄分布相似。与汉族相比，畲族的血压更高（128.0/79.7对121.5/76.9毫米汞柱，P <.001），且更频繁地报告饮酒（45.0%对27.7%；P <.001），但BMI（22.2对22.5千克/平方米；P =.05）和腰臀比更低（0.83对0.87；P <.001）。在畲族中，而非汉族中，BMI与饮酒量之间关于血压存在显著的相互作用（P <.01）。在BMI < 25千克/平方米的畲族中，饮酒者的血压显著高于不饮酒者（129.4/80.2对124.2/77.4毫米汞柱，P <.001），而在BMI≥25千克/平方米的畲族中，血压与饮酒量无关（134.3/84.9对136.8/85.7毫米汞柱，P >.41）。因此，在畲族中，饮酒者与BMI相关的血压斜率比不饮酒者更平缓（P <.01）。
在畲族中，饮酒量和BMI对血压有交互影响。需要进一步研究以阐明其潜在机制。
