A组链球菌实验室操作后产链球菌热原性外毒素的稳定性

Stability of streptococcal pyrogenic exotoxin production with laboratory manipulation of group A streptococci.

作者信息

Kaplan E L, Johnson D R, Wlazlo A, Kim M H, Schlievert P M

机构信息

Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455.

出版信息

J Infect Dis. 1991 Dec;164(6):1210-1. doi: 10.1093/infdis/164.6.1210.

DOI:10.1093/infdis/164.6.1210

PMID:1955721

Abstract

Because of reported differences in the production of streptococcal pyrogenic exotoxins by group A strains associated with severe streptococcal infections, the stability of exotoxin production by specific strains was examined by passing group A streptococci on blood agar culture plates daily for 20 days. No changes were detected in either exotoxin genes or in exotoxin production during this time, suggesting that these reported differences are due to other explanations such as differences in the strains collected from various geographic areas or to laboratory methodologic differences.

摘要

由于据报道与严重链球菌感染相关的A组菌株产生链球菌致热外毒素存在差异，通过在血琼脂培养平板上每日传代A组链球菌持续20天，检测特定菌株外毒素产生的稳定性。在此期间，外毒素基因和外毒素产生均未检测到变化，这表明这些报道的差异是由于其他解释，如从不同地理区域收集的菌株差异或实验室方法差异。