Choi Eun Ju, Kwon Hak Cheol, Sohn Young Chang, Nam Chun Woo, Park Hyun Bong, Kim Cheol Young, Yang Hyun Ok
Korea Institute of Science and Technology, Gangneung Institute, Gangneung 210-340, Korea.
Arch Pharm Res. 2009 Jun;32(6):851-5. doi: 10.1007/s12272-009-1606-2. Epub 2009 Jun 26.
A new prenylated dihydroflavonol, 3-hydroxy-kenusanone B 1, as well as three other known isoflavanones, sophoronol 2, sophoraisoflavanone A 3 and kenusanone H 4, were isolated from the rhizomes of Echinosophora koreensis. The structures of these compounds were elucidated using spectroscopic analyses that included extensive 2D NMR, optical rotation spectrometry and mass spectrometry. All four flavonoids enhanced the activities of alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) at micromolar concentrations. Sophoronol 2 showed a nine-fold increased activation of alcohol dehydrogenase and aldehyde dehydrogenase than a negative control group at concentrations of 100 microg/mL and 50 microg/mL, respectively. This study suggests that prenylated flavonoids have the potential to prevent 'hangovers' after alcohol intake.
从朝鲜刺果甘草的根茎中分离出一种新的异戊烯基二氢黄酮醇3-羟基-朝鲜刺果甘草酮B 1，以及其他三种已知的异黄酮，槐果醇2、槐果异黄酮A 3和朝鲜刺果甘草酮H 4。这些化合物的结构通过光谱分析得以阐明，光谱分析包括广泛的二维核磁共振、旋光光谱法和质谱法。所有四种黄酮类化合物在微摩尔浓度下均可增强乙醇代谢酶如乙醇脱氢酶（ADH）和乙醛脱氢酶（ALDH）的活性。在浓度分别为100μg/mL和50μg/mL时，槐果醇2对乙醇脱氢酶和乙醛脱氢酶的激活作用比阴性对照组分别高出9倍。本研究表明，异戊烯基黄酮类化合物具有预防饮酒后“宿醉”的潜力。
