An Su-Gyeong, Sohn Young-Taek
College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea.
Arch Pharm Res. 2009 Jun;32(6):933-6. doi: 10.1007/s12272-009-1616-0. Epub 2009 Jun 26.
The objective of this work was to investigate the existence of new polymorphs and pseudopolymorphs of atorvastatin and the transformation of crystal forms. Three crystal forms of atorvastatin have been isolated by recrystallization and characterized by powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG). The PXRD and DSC patterns of the three crystal forms were different respectively and it was confirmed that Form 3 is a new crystal form. After storage of 2 years at room temperature, this new crystal form was not transformed and it was shown to have a good physical stability.
这项工作的目的是研究阿托伐他汀新的多晶型物和假多晶型物的存在以及晶型的转变。通过重结晶分离出了阿托伐他汀的三种晶型，并通过粉末X射线衍射法（PXRD）、差示扫描量热法（DSC）和热重分析（TG）对其进行了表征。三种晶型的PXRD和DSC图谱分别不同，并且证实晶型3是一种新的晶型。在室温下储存2年后，这种新晶型没有发生转变，并且显示出良好的物理稳定性。
