髓过氧化物酶抗中性粒细胞胞浆抗体相关性血管炎伴弥漫性肾小管间质性肾炎。
Myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with diffuse tubulointerstitial nephritis.
作者信息
Son Daisuke, Kanda Hiroko, Yamaguchi Akihiro, Kawabata Kimito, Kawakami Takahisa, Kubo Kanae, Higashihara Mana, Shimizu Jun, Uozaki Hiroshi, Kuramochi Shigeru, Misaki Yoshikata, Takeuchi Fujio, Yamamoto Kazuhiko
机构信息
Department of Nephrology and Endocrinology, University of Tokyo, Tokyo - Japan.
出版信息
J Nephrol. 2009 May-Jun;22(3):417-20.
Renal involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is characterized by focal segmental crescentic and/or necrotizing glomerulonephritis. Here, we report the case of a 66-year-old woman showing myeloperoxidase (MPO)-ANCA positivity and mononeuritis multiplex whose kidney biopsy revealed severe and diffuse tubulointerstitial nephritis despite the fact that crescentic necrotizing glomerulonephritis was focal. The mechanism of tubulointerstitial injury in ANCA-associated vasculitis remains unclear. Further studies are necessary to confirm the relationship between diffuse tubulointerstitial nephritis and ANCA-associated vasculitis.
抗中性粒细胞胞浆抗体（ANCA）相关血管炎的肾脏受累表现为局灶节段性新月体性和/或坏死性肾小球肾炎。在此，我们报告一例66岁女性，其髓过氧化物酶（MPO）-ANCA阳性且有多发性单神经炎，尽管新月体坏死性肾小球肾炎是局灶性的，但肾脏活检显示为严重弥漫性肾小管间质性肾炎。ANCA相关血管炎中肾小管间质损伤的机制仍不清楚。需要进一步研究以证实弥漫性肾小管间质性肾炎与ANCA相关血管炎之间的关系。
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