Bittersohl Bernd, Hosalkar Harish S, Haamberg Tanja, Kim Young-Jo, Werlen Stefan, Siebenrock Klaus A, Mamisch Tallal C
Department of Orthopedic Surgery, Inselspital, Bern, Switzerland.
J Magn Reson Imaging. 2009 Jul;30(1):224-8. doi: 10.1002/jmri.21822.
To investigate the reproducibility of dGEMRIC in the assessment of cartilage health of the adult asymptomatic hip joint.
Fifteen asymptomatic volunteers (mean age, 26.3 years +/- 3.0) were preliminarily studied. Any volunteer that was incidentally diagnosed with damaged cartilage on MRI (n = 5) was excluded. Ten patients that had no evidence of prior cartilage damage (mean age, 26.2 years +/- 3.4) were evaluated further in this study. The reproducibility of dGEMRIC was assessed with two T1(Gd) exams performed 4 weeks apart in these volunteers. The protocol involved an initial standard MRI to confirm healthy cartilage, which was then followed by dGEMRIC. The second scan included only the repeat dGEMRIC. Region of interest (ROI) analyses for T1(Gd)-measurement was performed in seven radial reformats. Statistical analysis included the student's t-test and intra-class correlation (ICC) measurement to assess reproducibility.
Overall 70 ROIs were studied. Mean cartilage T1(Gd) values at various loci ranged from 560.9 ms to 684.4 ms at the first set of readings and 551.5 ms to 662.2 ms in the second one. The mean difference per region of interest between the two T1(Gd)-measurements ranged from 21.4 ms (3.7%) to 45.0 ms (6.8%), which was not found to be statistically significant (P = 0.153). There was a high reproducibility detected (ICC range, 0.667-0.915). Intra- and Inter-observer analyses proved a high agreement for T1(Gd) assessment (0.973 and 0.932).
We found dGEMRIC to be a reliable tool in the assessment of cartilage health status in adult hip joints.
研究磁共振成像延迟增强软骨容积成像（dGEMRIC）在评估成人无症状髋关节软骨健康状况时的可重复性。
对15名无症状志愿者（平均年龄26.3岁±3.0岁）进行初步研究。任何在磁共振成像（MRI）检查中被偶然诊断为软骨损伤的志愿者（n = 5）均被排除。本研究进一步评估了10名无既往软骨损伤证据的患者（平均年龄26.2岁±3.4岁）。在这些志愿者中，通过间隔4周进行的两次T1（钆）检查来评估dGEMRIC的可重复性。检查方案包括首先进行标准MRI以确认软骨健康，随后进行dGEMRIC检查。第二次扫描仅包括重复的dGEMRIC检查。在7个径向重组图像上进行了T1（钆）测量的感兴趣区（ROI）分析。统计分析包括学生t检验和组内相关系数（ICC）测量以评估可重复性。
共研究了70个ROI。在第一组读数时，不同位点的平均软骨T1（钆）值在560.9毫秒至684.4毫秒之间，第二组读数时为551.5毫秒至662.2毫秒。两次T1（钆）测量之间每个感兴趣区的平均差异在21.4毫秒（3.7%）至45.0毫秒（6.8%）之间，未发现具有统计学意义（P = 0.153）。检测到具有较高的可重复性（ICC范围为0.667 - 0.915）。观察者内和观察者间分析证明在T1（钆）评估方面具有高度一致性（分别为0.973和0.932）。
我们发现dGEMRIC是评估成人髋关节软骨健康状况的可靠工具。
