Shinozuka N, Okai T, Kuwabara Y, Mizuno M
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Oct;43(10):1341-7.
To investigate the development of sleep rhythm through the analysis of fetal behavior, the alteration of behavior was studied in cases with maternal antiepileptic drug (AED) administration (n = 13) in comparison with normal fetuses (n = 16). The subjects were classified into two groups according to gestational age (32 to 35 weeks and 36 to 40 weeks). The frequency of breathing movement (BM) and the REM and non-REM rhythm modes were affected by AED. The 32 to 35 week group showed an increase in the appearance rate (AP) of REM, a decrease in the duration of REM periods and normal non-REM periods. The 36 to 40 week group showed an increase in AP and prolonged REM periods while both non-REM periods decreased. A decrease in REM density of the REM period and a low BM frequency were distinctive findings in both groups. These results suggest that AED directly affects the fetal central nervous system, which regulates REM and non-REM sleep at a higher level, to alter sleep modes. The differences in the patterns of behavioral modulation of REM and non-REM rhythms in both gestational age groups induced by AED indicates the degree of central nervous system regulation of REM and non-REM rhythms.
为了通过分析胎儿行为来研究睡眠节律的发展，对母亲服用抗癫痫药物（AED）的病例（n = 13）与正常胎儿（n = 16）的行为变化进行了研究。根据胎龄（32至35周和36至40周）将受试者分为两组。呼吸运动（BM）频率以及快速眼动（REM）和非快速眼动节律模式受AED影响。32至35周组显示REM出现率（AP）增加，REM期持续时间减少，非REM期正常。36至40周组显示AP增加，REM期延长，而非REM期均减少。REM期REM密度降低和BM频率低是两组的显著发现。这些结果表明，AED直接影响胎儿中枢神经系统，该系统在更高水平上调节REM和非REM睡眠，从而改变睡眠模式。AED在两个胎龄组中诱导的REM和非REM节律行为调节模式的差异表明了中枢神经系统对REM和非REM节律的调节程度。
