Van der Linden Dimitri, Callens Steven, Brichard Bénédicte, Colebunders Robert
Cliniques Universitaires UCL St Luc, Pediatrics Department, 10 Avenue Hippocrate, 1200 Brussels, Belgium.
Expert Opin Pharmacother. 2009 Aug;10(11):1783-91. doi: 10.1517/14656560903012377.
Treating HIV-infected children remains a challenge due to a lack of treatment options, appropriate drug formulations and, in countries with limited resources, insufficient access to diagnostic tests and treatment.
To summarize current data concerning new opportunities to improve the treatment of HIV-infected children.
This review includes data from the most recently published peer-reviewed publications, guidelines or presentations at international meetings concerning new ways to treat HIV-infected children.
RESULTS/CONCLUSIONS: New WHO guidelines recommend starting combination antiretroviral treatment in all infants aged < 1 year. Although this is common practice in some high-income countries, implementation of these recommendations in countries with limited resources is still a challenge. There is still an important gap between the availability of licensed drugs in children compared with adults. There remains a need for further pharmacokinetic studies, and for more pediatric formulations of antiretroviral drugs with improved palatability.
由于缺乏治疗选择、合适的药物剂型，以及在资源有限的国家难以获得诊断检测和治疗，治疗感染艾滋病毒的儿童仍然是一项挑战。
总结有关改善感染艾滋病毒儿童治疗新机会的当前数据。
本综述纳入了最近发表的同行评审出版物、指南或国际会议上有关治疗感染艾滋病毒儿童新方法的报告中的数据。
结果/结论：世界卫生组织新指南建议对所有年龄小于1岁的婴儿开始联合抗逆转录病毒治疗。尽管这在一些高收入国家是常见做法，但在资源有限的国家实施这些建议仍然是一项挑战。与成人相比，儿童可用的获批药物之间仍存在重大差距。仍需要进一步开展药代动力学研究，并需要更多口感更佳的抗逆转录病毒药物儿科剂型。
