Department of Histopathology, Post Graduate Institute of Medical Sciences & Research, Chandigarh, India.
Diagn Pathol. 2009 Jun 28;4:21. doi: 10.1186/1746-1596-4-21.
Adult renal epithelial neoplasms are a heterogeneous group with varying prognosis and outcome requiring sub-classification.
Cases of renal cell carcinoma (RCC) in a 10 years period were analyzed with regard to the clinical features and histology. Sections were reviewed by four pathologists and the discordant cases were resolved with the help of Hale's colloidal iron stain, vimentin, CK 7, and vinculin immunostains and electron microscopy.
Amongst the total of 278 cases, clear cell renal cell carcinoma was the commonest tumor with 74.8% cases, followed by papillary RCC 12.2%, chromophobe RCC 7.9%, oncocytoma 1.8%, and one case of collecting duct RCC. Eight cases were of sarcomatoid renal cell carcinoma. In 28/278 cases, diagnoses varied amongst the four pathologists and the discordance was resolved by Hale's colloidal iron stain, CK7 immunostain and electron microscopy. Vimentin and vinculin did not contribute much in differentiating subtypes of renal cell carcinomas. Relative incidence of sub-types of RCCs was compared with other series.
To accurately subclassify renal cell carcinomas, simple ancillary techniques would possibly resolve all difficult cases. The relative incidence of sub-types of renal cell carcinoma is relatively consistent the world over. However, in India, RCCs afflict the patients two decades earlier.
成人肾上皮性肿瘤是一组异质性肿瘤，具有不同的预后和转归，需要进行亚分类。
分析了 10 年间的肾细胞癌（RCC）病例，分析了其临床特征和组织学。由四位病理学家对切片进行了复查，通过 Hale 胶体铁染色、波形蛋白、CK7 和 vinculin 免疫染色和电子显微镜解决了不一致的病例。
在总共 278 例中，透明细胞肾细胞癌是最常见的肿瘤，占 74.8%，其次是乳头状 RCC 占 12.2%，嫌色细胞 RCC 占 7.9%，嗜酸细胞瘤占 1.8%，1 例集合管 RCC。8 例为肉瘤样肾细胞癌。在 278 例中，有 28 例诊断存在四位病理学家之间的差异，通过 Hale 胶体铁染色、CK7 免疫染色和电子显微镜解决了不一致的情况。波形蛋白和 vinculin 对区分肾细胞癌的亚型没有太大帮助。与其他系列相比，比较了 RCC 各亚型的相对发生率。
为了准确地对肾细胞癌进行亚分类，简单的辅助技术可能会解决所有困难的病例。肾细胞癌各亚型的相对发生率在世界各地相对一致。然而，在印度，RCC 使患者在 20 年前就受到了影响。
