Pifarré-Montaner P, Fernández-León A, de Juan R, del Ama-Salvador M E, Galán M, Gámez-Cenzano C, Sans M
Unidad de PET, IDI, Hospital Universitario de Bellvitge, Barcelona, España.
Rev Esp Med Nucl. 2009 May-Jun;28(3):101-5.
The incidence of esophageal cancer has increased considerably over recent years, it now being the 6th most frequent cause of cancer-related death. Our study has aimed to compare the clinical value of PET/CT and CT scan in the initial staging of patients with esophageal cancer.
Fifty nine patients (6 women) diagnosed of esophageal cancer were assessed retrospectively. All patients underwent diagnostic CT scan and PET/CT for initial staging within 3 to 15 days following clinical diagnosis.
PET/CT showed intracellular (18)F-FDG entrapment having pathological significance in all the tumors (100%), signs of locoregional lymph node infiltration (N1) in 34 and a total of 19 lesions consistent with metastasis (M1) in 14 patients (23.72%). The CT scan detected malignancy in 57 patients (96.6%), abnormal lymph node in 32 patients and 17 N1 in 12 patients (20.33%). In three cases, CT- PET detected synchronous esophageal lesion in staging studies for other neoplastic processes (lung and ear-nose-throat).
PET/CT showed a higher detection rate of primary malignant lesions, abnormal lymph nodes and distant metastases. A change in stage was only observed in two patients.
近年来食管癌的发病率显著上升，目前它是癌症相关死亡的第六大常见原因。我们的研究旨在比较PET/CT和CT扫描在食管癌患者初始分期中的临床价值。
回顾性评估了59例（6名女性）诊断为食管癌的患者。所有患者在临床诊断后的3至15天内接受了诊断性CT扫描和PET/CT以进行初始分期。
PET/CT显示所有肿瘤（100%）中具有病理意义的细胞内（18）F-FDG滞留，34例出现局部区域淋巴结浸润（N1）迹象，14例患者（23.72%）共有19个病灶符合转移（M1）。CT扫描在57例患者（96.6%）中检测到恶性肿瘤，32例患者有异常淋巴结，12例患者有17个N1（20.33%）。在3例病例中，CT-PET在其他肿瘤（肺和耳鼻喉）的分期研究中检测到同步食管病变。
PET/CT对原发性恶性病变、异常淋巴结和远处转移的检出率更高。仅在2例患者中观察到分期变化。
