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首例成功应用顺行单气囊小肠镜检查法对一名3岁隐匿性消化道出血患儿进行诊治。

First successful antegrade single-balloon enteroscopy in a 3-year-old with occult GI bleeding.

作者信息

Kramer Robert E, Brumbaugh David E, Soden Jason S, Capocelli Kelley E, Hoffenberg Edward J

机构信息

Section of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children's Hospital/University of Colorado Denver, Denver, Colorado, USA.

出版信息

Gastrointest Endosc. 2009 Sep;70(3):546-9. doi: 10.1016/j.gie.2009.04.011. Epub 2009 Jun 25.

Abstract

BACKGROUND

Balloon enteroscopy is an emerging technique to allow access to the small intestine for both diagnostic and therapeutic purposes. To date, there have been few published data documenting the safety and efficacy of balloon enteroscopy in small children.

OBJECTIVE

To describe our experience with single-balloon enteroscopy (SBE) in a 37-month-old toddler with occult GI bleeding.

DESIGN

A single case report.

SETTING

A free-standing, academic children's hospital in Denver, Colorado.

PATIENT

The patient was a 37-month-old, 13.5-kg toddler with persistent heme-positive stools, severe microcytic anemia, and hypoalbuminemia. Previous workup was significant for eosinophilic inflammation in the antrum and a video capsule study showing erythematous lesions in the small bowel.

INTERVENTION

An antegrade SBE was performed with the child under general endotracheal anesthesia, with biopsy specimens obtained from identified lesions in the jejunum and ileum.

MAIN OUTCOME MEASUREMENTS

Complications and successful treatment of symptoms were the primary endpoints.

RESULTS

The procedure was performed successfully in 85 minutes, passing an estimated 200 cm beyond the pylorus, without complications. Identification of the lesions as consistent with eosinophilic enteropathy led to successful treatment with an elimination diet and corticosteroids.

LIMITATIONS

The primary limitation of this study is that it is a single case report. Therefore, it is difficult to make a generalized statement regarding the safety and efficacy of balloon enteroscopy in toddlers of this size.

CONCLUSIONS

Antegrade SBE can be a well-tolerated and effective procedure to evaluate occult GI bleeding in children as young as 3 years of age. Further study is needed to better establish safety parameters for balloon enteroscopy in small pediatric patients.

摘要

背景

气囊小肠镜检查是一种新兴技术,可用于小肠的诊断和治疗。迄今为止,关于小儿气囊小肠镜检查安全性和有效性的已发表数据很少。

目的

描述我们对一名37个月大患有隐匿性胃肠道出血幼儿进行单气囊小肠镜检查(SBE)的经验。

设计

单病例报告。

地点

科罗拉多州丹佛市一家独立的学术儿童医院。

患者

该患者为一名37个月大、体重13.5千克的幼儿,持续性粪便潜血阳性、严重小细胞性贫血和低白蛋白血症。先前的检查显示胃窦嗜酸性炎症,视频胶囊研究显示小肠有红斑性病变。

干预

在全身气管内麻醉下对患儿进行顺行SBE,并从空肠和回肠的病变处获取活检标本。

主要观察指标

并发症和症状的成功治疗是主要终点。

结果

手术在85分钟内成功完成,估计越过幽门200厘米,无并发症。病变被确定为符合嗜酸性肠病,通过饮食排除和使用皮质类固醇成功治疗。

局限性

本研究的主要局限性在于它是单病例报告。因此,很难就这种大小幼儿气囊小肠镜检查的安全性和有效性做出一般性陈述。

结论

顺行SBE对于评估年仅3岁儿童的隐匿性胃肠道出血可能是一种耐受性良好且有效的方法。需要进一步研究以更好地确定小儿患者气囊小肠镜检查的安全参数。

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