Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
J Cardiopulm Rehabil Prev. 2009 Sep-Oct;29(5):314-7. doi: 10.1097/HCR.0b013e3181ac785f.
It has been shown that behavioral therapy has effects on stress behavior in patients with coronary artery disease. Salivary cortisol measurements are widely used to assess psychological stress, stress reactivity, or both. The aim of this study was to investigate whether improved stress behavior in type A patients with coronary artery disease involved changes in cortisol secretion pattern.
Twenty-four male patients were identified as type A individuals and completed a 12-month cognitive-behavioral stress management program. Stress behavior was evaluated by using a validated questionnaire. Morning and evening salivary cortisol levels were measured over 3 consecutive days at baseline and after 12 months.
Although the patients showed a significant improvement in psychosocial well-being after 12 months, their basal cortisol levels or diurnal rhythm of cortisol did not change. There was no correlation between stress score and cortisol levels.
The value of salivary cortisol as both a stress marker and a new cardiovascular risk factor has been discussed but the data from this small pilot study raise the question of its utility as a stress marker in cardiac rehabilitation.
研究表明，行为疗法对冠心病患者的应激行为有影响。唾液皮质醇测量被广泛用于评估心理应激、应激反应或两者兼而有之。本研究旨在探讨冠心病 A 型患者的应激行为改善是否涉及皮质醇分泌模式的变化。
确定 24 名男性患者为 A 型个体，并完成了为期 12 个月的认知行为应激管理方案。应激行为通过使用经过验证的问卷进行评估。在基线和 12 个月后，连续 3 天测量早晨和晚上的唾液皮质醇水平。
尽管患者在 12 个月后表现出明显的心理健康改善，但他们的基础皮质醇水平或皮质醇的昼夜节律没有变化。应激评分与皮质醇水平之间没有相关性。
唾液皮质醇作为应激标志物和新的心血管风险因素的价值已被讨论，但这项小型试点研究的数据提出了其作为心脏康复中应激标志物的实用性问题。
Zotero 插件