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发展中国家被忽视的问题:非囊性纤维化性支气管扩张症。

A neglected problem of developing countries: Noncystic fibrosis bronchiectasis.

机构信息

Department of Pediatric Allergy, Dokuz Eylul University Medical School, Balcova, 35340, Izmir, Turkey.

出版信息

Ann Thorac Med. 2009 Jan;4(1):21-4. doi: 10.4103/1817-1737.44781.

Abstract

BACKGROUND

Bronchiectasis has been defined as the abnormal and permanent dilation of the bronchi. It is still an important problem in many developing countries.

AIM

The aim of this study was to identify the chacteristics and underlying etiology of children followed with the diagnosis of noncystic fibrosis bronchiectasis.

MATERIALS AND METHODS

Children with bronchiectasis confirmed with high-resolution computed tomography were enrolled into the study. The data of the patients, including symptoms of the disease, age at the onset of symptoms, findings of physical examination, labrotory investigations performed in order to identify the etiology of bronchiectasis, etiology of bronchiectasis if found, radiologic findings and treatment modalities were noted.

RESULTS

Sixty-six children between 1 and 17 years were included in the study retrospectively. Forty-four of them were males (66.7%) and 22 (33.3%) were females. The most common presenting symptoms were cough (100%) and sputum expectoration (50%). An underlying etiology was identified in 44 (66.7%) of the study subjects. The four most common underlying causes were found as infections (21.2%), asthma (16.7%), aspiration syndromes and/or gastroesophageal reflux disease (9.1%) and immunodeficiency syndromes (7.6%), respectively.

CONCLUSION

Identifying an underlying etiology will have a significant effect on the management of noncystic fibrosis bronchiectasis. Defining the cause of bronchiectasis may also decrease its incidence, progression and complications.

摘要

背景

支气管扩张症被定义为支气管的异常和永久性扩张。它在许多发展中国家仍然是一个重要的问题。

目的

本研究的目的是确定非囊性纤维化性支气管扩张症患儿的特征和潜在病因。

材料和方法

本研究纳入了经高分辨率计算机断层扫描(HRCT)确诊为支气管扩张症的患儿。记录了患者的资料,包括疾病的症状、症状发作的年龄、体格检查结果、为确定支气管扩张症病因而进行的实验室检查、如果发现病因、影像学表现和治疗方法。

结果

本研究回顾性纳入了 66 名 1 至 17 岁的儿童。其中 44 名男性(66.7%),22 名女性(33.3%)。最常见的症状是咳嗽(100%)和咳痰(50%)。在 44 名(66.7%)研究对象中确定了潜在病因。最常见的四个潜在病因分别为感染(21.2%)、哮喘(16.7%)、吸入综合征和/或胃食管反流病(9.1%)和免疫缺陷综合征(7.6%)。

结论

确定潜在病因将对非囊性纤维化性支气管扩张症的管理产生重大影响。确定支气管扩张症的病因也可能降低其发病率、进展和并发症。

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