Charité-Universitaetsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik IV, Berlin, Germany.
Br J Pharmacol. 2009 Aug;157(7):1142-53. doi: 10.1111/j.1476-5381.2009.00337.x. Epub 2009 Jun 25.
The purinergic system is composed of mononucleosides, mononucleoside polyphosphates and dinucleoside polyphosphates as agonists, as well as the respective purinergic receptors. Interest in the role of the purinergic system in cardiovascular physiology and pathophysiology is on the rise. This review focuses on the overall impact of dinucleoside polyphosphates in the purinergic system. Platelets, adrenal glands, endothelial cells, cardiomyocytes and tubular cells release dinucleoside polyphosphates. Plasma concentrations of dinucleoside polyphosphates are sufficient to cause direct vasoregulatory effects and to induce proliferative effects on vascular smooth muscle cells and mesangial cells. In addition, increased plasma concentrations of a dinucleoside polyphosphate were recently demonstrated in juvenile hypertensive patients. In conclusion, the current literature accentuates the strong physiological and pathophysiological impact of dinucleoside polyphosphates on the cardiovascular system.
嘌呤能系统由单核苷酸、单核苷酸多聚磷酸和二核苷酸多聚磷酸作为激动剂,以及各自的嘌呤能受体组成。人们对嘌呤能系统在心血管生理学和病理生理学中的作用的兴趣正在上升。本综述重点介绍了二核苷酸多聚磷酸在嘌呤能系统中的整体影响。血小板、肾上腺、内皮细胞、心肌细胞和管状细胞释放二核苷酸多聚磷酸。血浆中二核苷酸多聚磷酸的浓度足以引起直接的血管调节作用,并诱导血管平滑肌细胞和肾小球系膜细胞的增殖作用。此外,最近在青少年高血压患者中证明了血浆中二核苷酸多聚磷酸浓度的增加。总之,目前的文献强调了二核苷酸多聚磷酸对心血管系统具有很强的生理和病理生理学影响。