Facultad de Ciencias del Medio Ambiente, Universidad de Castilla-La Mancha. Real Fábrica de Armas, Avda. Carlos III, Toledo, Spain.
Bioessays. 2009 Aug;31(8):865-73. doi: 10.1002/bies.200800231.
Stomata, the most influential components in gas exchange with the atmosphere, represent a revealing system for studying cell fate determination. Studies in Arabidopsis thaliana have demonstrated that many of the components, functioning in a signaling cascade, guide numerous cell fate transitions that occur during stomatal development. The signaling cascade is initiated at the cell surface through the activation of the membrane receptors TOO MANY MOUTHS (TMM) and/or ERECTA (ER) family members by the secretory peptide EPIDERMAL PATTERNING FACTOR1 (EPF1) and/or a substrate processed proteolytically by the subtilase STOMATAL DENSITY AND DISTRIBUTION1 (SDD1) and transduced through cytoplasmic MAP kinases (YODA (YDA), MKK4/MKK5, and MPK3/MPK6) towards the nucleus. In the nucleus, these MAP kinases regulate the activity of the basic helix-loop-helix (bHLH) proteins SPEECHLESS (SPCH), MUTE, and FAMA, which act in concert with the bHLH-Leu zipper protein SCREAM (SCRM) (and/or its closely related paralog, SCREAM2). This article reviews current insights into the role of this signaling cascade during stomatal development.
气孔是与大气进行气体交换的最具影响力的组成部分，代表了一个用于研究细胞命运决定的揭示系统。拟南芥的研究表明，许多在信号级联中发挥作用的成分，指导了在气孔发育过程中发生的许多细胞命运转变。信号级联通过由分泌肽表皮图案形成因子 1（EPF1）和/或由枯草杆菌蛋白酶处理的基质启动，通过质膜受体 TOO MANY MOUTHS（TMM）和/或 ERECTA（ER）家族成员的激活启动，并且通过细胞质 MAP 激酶（YODA（YDA），MKK4/MKK5 和 MPK3/MPK6）向细胞核转导。在细胞核中，这些 MAP 激酶调节基本螺旋环-螺旋（bHLH）蛋白 SPEECHLESS（SPCH）、MUTE 和 FAMA 的活性，它们与 bHLH-Leu 拉链蛋白 SREAM（SCRM）（和/或其密切相关的同源物，SCREAM2）协同作用。本文综述了目前对该信号级联在气孔发育过程中的作用的认识。
