[红曲发酵姜黄素对高脂血症小鼠降血脂特性的研究]

[Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus].

作者信息

Cheng Dong-Qing, Wo Xing-De, Pan Pei-Lei, Yu Sheng-Bo, Xu Bing-Hai

机构信息

Beijing University of Chinese Medicine, Beijing 100029, China.

出版信息

Zhong Yao Cai. 2009 Mar;32(3):388-91.

PMID:19565718

Abstract

OBJECTIVE

To study the lipids reducing property of curcumin on Hyperlipidemia mice after fermented by Monascus purureus.

METHODS

The stain Monascus purureus was used for microbial transformation, and both substrate control and strain control were set. The mice were reared with high lipid and cholesterol feed for 15d to establish the Hyperlipidemia models. The models were treated with fermented curcumin in 500 mg/kg, 200 mg/kg, 100 mg/kg, substrate control and strain control in 500 mg/kg. Positive and Normal group were treated with natural saline. The general situation was observed and the changes of TG, TC, HDL-C levels in serum and liver were tested after 10 d.

RESULTS

Fermented curcumin could significantly reduce the serum TC, TG of Hyperlipidemia mice all in high, middle and low doses. Serum TC was reduced by 38.7%, 34.5%, 32.7% and TG was reduced by 38.3%, 28.6%, 30.1%, respectively while substrate control and strain control had no effect. Fermented curcumin also could reduce the TC, TG in liver but no effect of curcumin substrate at the same dose.

CONCLUSION

The property of lipids reducing of curcumin is significantly enhanced after fermentation.

摘要

目的

研究红曲发酵姜黄素对高脂血症小鼠的降脂作用。

方法

采用红曲进行微生物转化，设置底物对照和菌株对照。用高脂高胆固醇饲料喂养小鼠15天以建立高脂血症模型。模型分别用500mg/kg、200mg/kg、100mg/kg的发酵姜黄素、500mg/kg的底物对照和菌株对照进行处理。阳性组和正常组用生理盐水处理。观察一般情况，并在10天后检测血清和肝脏中TG、TC、HDL-C水平的变化。