Acupuncture and moxibustion is a technique of TCM with the most tremendous influence in international, its standardization will be of important significance for promoting TCM widely spreading in international. Point application is one of important compositions of acupuncture and moxibustion techniques. Development of manipulation standardization of acupoint application technique is an important measure for increasing medical quality, ensuring medical safety and preventing medical risks, and this is of important significance for scientific studies and clinical popularization of point application technique. In the present paper, the difficult points, resolving way and standard technique characteristics, the attention problems and defects in usage in development course of manipulation standardization of acupoint application technique are discussed.