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西印度群岛大学医院尿路结石的化学成分

Chemical composition of urinary tract stones at the University Hospital of the West Indies.

作者信息

Choo-Kang E

机构信息

Department of Pathology, The University of the West Indies, Kingston 7, Jamaica.

出版信息

West Indian Med J. 2008 Nov;57(5):427-30.

Abstract

Urinary tract stones occur frequently with the incidence being about one to fifteen per cent worldwide. Patients may be asymptomatic or sometimes they may present with haematuria. Severe lumbar pain radiating to the loin requiring immediate analgesic treatment may occur Stones generally consist of organic and inorganic material. The organic material may be present in the nidus and can contribute up to about 2.5% of the total weight. Inorganic minerals make up the bulk of the stone. Data are presented for the inorganic minerals present in the stones seen at the University Hospital of the West Indies over a 25-year period. Six hundred and forty-one (445 males and 196females) stones were analyzed by routine chemical methods. Calcium was the main constituent, being seen in 93.9% of the stones. This was followed by oxalate 60.1%, urate 37.0%, bicarbonate 16.5% and magnesium 8.6%. There were four cystine containing stones. Treatment includes medical management for the underlying cause and surgical methods for the removal of the stones. Chemical methods of analysis of the stones has its limitations and should be replaced by more sophisticated methods eg X-ray diffraction crystallography which would give more accurate details of the structure of the stones.

摘要

尿路结石很常见,全球发病率约为1%至15%。患者可能无症状,有时可能出现血尿。可能会出现严重的腰痛并放射至腰部,需要立即进行止痛治疗。结石通常由有机和无机物质组成。有机物质可能存在于结石核心中,占总重量的比例可达约2.5%。无机矿物质构成了结石的大部分。本文给出了西印度群岛大学医院在25年期间所见到的结石中无机矿物质的数据。通过常规化学方法分析了641颗结石(445颗男性结石和196颗女性结石)。钙是主要成分,在93.9%的结石中可见。其次是草酸盐60.1%、尿酸盐37.0%、碳酸氢盐16.5%和镁8.6%。有4颗含胱氨酸的结石。治疗包括针对潜在病因的内科治疗以及去除结石的外科方法。结石的化学分析方法有其局限性,应由更先进的方法(如X射线衍射晶体学)取代,后者能给出结石结构更准确的细节。

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