Rahman Khondaker M, Reszka Anthony P, Gunaratnam Mekala, Haider Shozeb M, Howard Philip W, Fox Keith R, Neidle Stephen, Thurston David E
Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK WC1N 1AX.
Chem Commun (Camb). 2009 Jul 21(27):4097-9. doi: 10.1039/b902359c. Epub 2009 Jun 5.
We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.
我们报道了一类新型的联芳基聚酰胺，其对G-四链体DNA具有高度选择性，并且在几种癌细胞系中具有显著的细胞毒性；它们形成平面U形结构，该结构与四链体结构中末端G-四重体的表面积尺寸相匹配，而非双链DNA的沟槽。
