一种用于检测时间周期性模式中断的振荡电路。
An oscillatory circuit underlying the detection of disruptions in temporally-periodic patterns.
作者信息
Gao Juan, Schwartz Greg, Berry Michael J, Holmes Philip
机构信息
Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.
出版信息
Network. 2009;20(2):106-35. doi: 10.1080/09548980902991705.
Neurons in diverse brain areas can respond to the interruption of a regular stimulus pattern by firing bursts of spikes. Here we describe a simple model, which permits such responses to periodic stimuli over a substantial frequency range. Focusing on the omitted stimulus response (OSR) in isolated retinas subjected to periodic patterns of dark flashes, we develop a biophysically-realistic model which accounts for resonances in ON bipolar cells. The bipolar cell terminal contains an LRC oscillator whose inductance is modulated by a transient calcium concentration, thus adjusting its resonant frequency to approximately match that of the stimulus. The model reproduces ganglion cell outputs, which sum the ON and OFF bipolar pathways, and it responds to omitted flashes with approximately constant latencies, as observed experimentally.
不同脑区的神经元能够通过发放一串脉冲来对规则刺激模式的中断做出反应。在此，我们描述了一个简单模型，该模型能够在相当大的频率范围内对周期性刺激做出此类反应。聚焦于接受周期性暗闪光模式刺激的离体视网膜中的遗漏刺激反应（OSR），我们构建了一个生物物理现实模型，该模型考虑了ON双极细胞中的共振现象。双极细胞终末包含一个LRC振荡器，其电感由瞬时钙浓度调制，从而将其共振频率调整到大致与刺激频率相匹配。该模型再现了对ON和OFF双极通路进行求和的神经节细胞输出，并且如实验观察到的那样，它以大致恒定的潜伏期对遗漏闪光做出反应。
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