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基于进化的医学(ebm)是一种认识论框架,用于思考和应对所谓的“医学危机”。

Evolution based medicine (ebm) an epistemological framework for thinking of, and dealing with the so called "crisis of medicine".

作者信息

Corbellini Gilberto

机构信息

Section of History of Medicine, Sapienza-University of Rome, Rome, Italy.

出版信息

Med Secoli. 2008;20(1):115-39.

Abstract

A growing interest toward the evolutionary or Darwinian approaches in medicine stimulates today's debates about the future of medical knowledge and practice. A rising number of symposia, essays, and books are questioning if medicine still makes sense without evolution, arguing that an understanding of how natural selection shaped human vulnerability to disease could provide new insights into medical research and practice, and contribute to a more pertinent idea of health and disease than the ones emerging from the understanding of physiology and biochemistry. The aim of this paper is to provide an historical and epistemological perspective for an evolution based medicine (ebm). Starting from a schematic analysis of the most controversial issues debated within the literature dealing with the so called "crisis of medicine", I will guess that medical theory and philosophy of medicine find it difficult to manage the crisis because they are suffering from a historical fallacy. A schematic reconstruction of the historical advancements of medical epistemology, both at the level of theoretical thinking and of methodological strategies will then be put forward, to demonstrate the epistemological pluralism of medicine. Instead of considering medical pluralism as a demonstration that medical knowledge is socially constructed, the essay argues that it is a consequence of the fact that the living beings who become sick and those that try to understand how and why it happens are temporary endpoints of the ongoing process of biological evolution by natural selection. The main assumptions and theories which inspire "evolution based medicine" will finally be listed and analyzed in terms of their the epistemological implications, showing why and how an evolutionary and Darwinian perspective about medical knowledge and practice can improve and complete the epistemological understanding and foundation of medicine.

摘要

如今,人们对医学中进化或达尔文主义方法的兴趣与日俱增,这引发了关于医学知识与实践未来的诸多讨论。越来越多的研讨会、论文和书籍都在质疑,如果没有进化,医学是否还有意义,他们认为,理解自然选择如何塑造人类对疾病的易感性,能够为医学研究与实践提供新的见解,而且相较于基于生理学和生物化学的理解所产生的健康与疾病观念,能促成更切题的健康与疾病理念。本文旨在为基于进化的医学(ebm)提供一个历史和认识论视角。从对文献中所讨论的最具争议性问题(即所谓的“医学危机”)进行概要分析入手,我推测医学理论和医学哲学难以应对这场危机,因为它们正遭受一种历史谬误的影响。接下来将对医学认识论在理论思维和方法论策略层面的历史进展进行概要重构,以证明医学的认识论多元性。本文并非将医学多元性视为医学知识是社会建构的一种证明,而是认为它是这样一个事实的结果:患病的生物以及试图理解疾病发生方式和原因的生物,都是自然选择驱动的生物进化这一持续过程的暂时终点。最后将列出并分析激发“基于进化的医学”的主要假设和理论,并探讨其认识论意义,说明为何以及如何从进化和达尔文主义视角看待医学知识与实践能够完善并充实医学的认识论理解和基础。

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