Rockwell S, Kelley M, Irvin C G, Hughes C S, Porter E, Yabuki H, Fischer J J
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510-8040.
Radiother Oncol. 1991 Oct;22(2):92-8. doi: 10.1016/0167-8140(91)90003-y.
The effect of a concentrated perfluorooctylbromide emulsion (Oxygent) on the radiosensitivity and oxygenation of solid tumors was examined using EMT6 mammary tumors in BALB/c mice and BA1112 rhabdomyosarcomas in WAG/rij rats. Treatment with Oxygent plus carbogen or oxygen breathing increased the radiosensitivity of both tumors. Analysis of tumor cell survival data and polarographic measurements of intratumoral pO2 indicated that this potentiation reflected an increase in the proportion of well-oxygenated tumor cells. Treatments with carbogen breathing alone, with Oxygent plus air-breathing, or with a vehicle emulsion containing all the components except the perfluorocarbon did not produce comparable improvements in tumor radiosensitivity. Concentrated perfluorooctylbromide emulsions appear to warrant further development and preclinical testing as adjuncts to cancer therapy.
使用BALB/c小鼠的EMT6乳腺肿瘤和WAG/rij大鼠的BA1112横纹肌肉瘤，研究了全氟辛基溴浓缩乳剂（Oxygent）对实体瘤放射敏感性和氧合作用的影响。用Oxygent加二氧化碳混合气或吸氧治疗可提高两种肿瘤的放射敏感性。肿瘤细胞存活数据的分析和瘤内pO2的极谱测量表明，这种增效作用反映了富氧肿瘤细胞比例的增加。单独呼吸二氧化碳混合气、Oxygent加空气呼吸或使用不含全氟碳化合物但含有所有其他成分的载体乳剂进行治疗，均未在肿瘤放射敏感性方面产生类似的改善。全氟辛基溴浓缩乳剂似乎值得作为癌症治疗的辅助手段进行进一步开发和临床前测试。
