Shimokawa Y, Okuda K, Kubo Y, Kaneko A, Arishima T, Nagata E, Hashimoto M, Sawa Y, Nagasaki Y, Kojiro M, Sakamoto K, Nakashima T
Cancer. 1977 Jul;40(1):319-24. doi: 10.1002/1097-0142(197707)40:1<319::aid-cncr2820400145>3.0.co;2-q.
Serum enzyme activities were studied in 131 cases of hepatocellular carcinoma (HCC), 76 cases of metastatic liver carcinomas (MLC) and 234 cases of hepatic cirrhosis. SGOT was elevated above SGPT in most of the time in these patients, SGOT/SGPT was greater in HCC compared with other groups, and that this ratio increased during the preterminal period more markedly in patients with HCC because of the significant increase of SGOT in the face of relatively stable SGPT. Preterminal rises of alkaline phosphatase and LDH activities were more pronounced in MLC. Leucine aminopeptidase activity exhibited no characteristic feature of diagnostic value. Of the five enzymes, SGOT changes were more closely correlated with the growth of HCC; SGPT reflected more of the liver parenchymal damage while SGOT was probably accounted for in part by tumor-derived GOT. Other clinical and pathological implications are discussed.
对131例肝细胞癌（HCC）、76例转移性肝癌（MLC）和234例肝硬化患者的血清酶活性进行了研究。在这些患者中，大多数时候谷草转氨酶（SGOT）高于谷丙转氨酶（SGPT），与其他组相比，HCC患者的SGOT/SGPT比值更高，并且由于在相对稳定的SGPT情况下SGOT显著升高，HCC患者在终末期前该比值升高更为明显。终末期前碱性磷酸酶和乳酸脱氢酶（LDH）活性在MLC中升高更为显著。亮氨酸氨肽酶活性未表现出具有诊断价值的特征。在这五种酶中，SGOT变化与HCC的生长更密切相关；SGPT更多地反映肝实质损伤，而SGOT可能部分由肿瘤源性谷草转氨酶所致。还讨论了其他临床和病理意义。
