Sacco Simona, Totaro Rocco, Toni Danilo, Marini Carmine, Cerone Davide, Carolei Antonio
Department of Neurology, University of L'Aquila, IT-67010 L'Aquila, Italy.
Eur Neurol. 2009;62(3):155-60. doi: 10.1159/000226617. Epub 2009 Jul 2.
To evaluate incidence, case fatalities and prognosis of subarachnoid hemorrhage (SAH).
Prospective population-based registry (1994-1998) including patients with a first-ever stroke followed up to 10 years.
In a 5-year period we included 118 patients (55 men and 63 women; mean age +/- SD 60.7 +/- 15.9 years) with an SAH. The crude annual incidence rate was 7.93 cases per 100,000 inhabitants (95% CI 6.46-9.63), 7.60 per 100,000 when standardized to the 2006 European population and 5.27 per 100,000 when standardized to the 2005 world population. The 7-day case-fatality rate was 16.1% (95% CI 9.5-22.7), 30-day case-fatality rate was 34.7% (95% CI 21.2-43.3), and 1-year case-fatality rate was 44.9% (95% CI 35.9-53.9). At the end of the 1-year follow-up, 53 patients (44.9%) had a good recovery [modified Rankin scale (mRS) 0-2] and 12 (10.2%) had a severe disability (mRS 3-5). The 10-year survival rate was 46.4% (95% CI 36.0-57.8).
In our district, the SAH incidence rate was similar to what is reported in most European countries. Since more than half of the patients with SAH remained severely disabled or died, results from our population-based study strongly support the notion that the most appropriate treatments should be made available for all patients in comprehensive centers and the call for an urgent implementation of telemedicine in the rural areas of our district.
评估蛛网膜下腔出血(SAH)的发病率、病死率及预后情况。
基于人群的前瞻性登记研究(1994 - 1998年),纳入首次发生卒中的患者并随访10年。
在5年期间,我们纳入了118例SAH患者(55例男性和63例女性;平均年龄±标准差60.7±15.9岁)。粗年发病率为每10万居民7.93例(95%可信区间6.46 - 9.63),按2006年欧洲人口标准化后为每10万7.60例,按2005年世界人口标准化后为每10万5.27例。7天病死率为16.1%(95%可信区间9.5 - 22.7),30天病死率为34.7%(95%可信区间21.2 - 43.3),1年病死率为44.9%(95%可信区间35.9 - 53.9)。在1年随访结束时,53例患者(44.9%)恢复良好[改良Rankin量表(mRS)0 - 2],12例患者(10.2%)有严重残疾(mRS 3 - 5)。10年生存率为46.4%(95%可信区间36.0 - 57.8)。
在我们地区,SAH发病率与大多数欧洲国家报道的相似。由于超过一半的SAH患者仍严重残疾或死亡,我们基于人群的研究结果有力地支持了这样一种观点,即综合中心应为所有患者提供最合适的治疗,并呼吁在我们地区农村地区紧急实施远程医疗。