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Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues.
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Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide.
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Fluorescent probes for nucleic Acid visualization in fixed and live cells.
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Programmable DNA-binding small molecules.
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In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography.
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13039-44. doi: 10.1073/pnas.0806308105. Epub 2008 Aug 27.
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Hydrolytic stability of hydrazones and oximes.
Angew Chem Int Ed Engl. 2008;47(39):7523-6. doi: 10.1002/anie.200802651.
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Inhibition of transcription factors with small organic molecules.
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Targeting transcription factors for therapeutic benefit.
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Completion of a Programmable DNA-Binding Small Molecule Library.
Tetrahedron. 2007 Jul 2;63(27):6146-6151. doi: 10.1016/j.tet.2007.03.041.
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Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit.
J Am Chem Soc. 2008 May 28;130(21):6859-66. doi: 10.1021/ja800888d. Epub 2008 May 7.
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Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface.
ACS Chem Biol. 2007 Aug 17;2(8):561-71. doi: 10.1021/cb700110z.
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Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide.
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10418-23. doi: 10.1073/pnas.0704217104. Epub 2007 Jun 12.
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Improved nuclear localization of DNA-binding polyamides.
Nucleic Acids Res. 2007;35(2):363-70. doi: 10.1093/nar/gkl1042. Epub 2006 Dec 14.
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DMSO-related effects in protein characterization.
J Biomol Screen. 2006 Mar;11(2):131-7. doi: 10.1177/1087057105284218. Epub 2006 Feb 20.

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