硫肽类抗生素吡啶-噻唑核心结构的改进合成方法。
An improved synthesis of pyridine-thiazole cores of thiopeptide antibiotics.
作者信息
Aulakh Virender S, Ciufolini Marco A
机构信息
Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
出版信息
J Org Chem. 2009 Aug 7;74(15):5750-3. doi: 10.1021/jo900950x.
PMID:19572592
Abstract
The oxidation of 2-methylthiazoles to 2-formylthiazoles simplifies the implementation of the Bagley variant of the Bohlmann-Rahtz reaction as a key step in a concise new route to pyridine cores of thiopeptide antibiotics.
摘要
将2-甲基噻唑氧化为2-甲酰基噻唑，简化了Bohlmann-Rahtz反应的Bagley变体的实施，这是硫肽抗生素吡啶核心简洁新路线中的关键步骤。
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