Bohlmann-Rahtz 环脱水反应：使用 N-碘代丁二酰亚胺将氨二烯酮转化为吡啶。
Bohlmann-Rahtz cyclodehydration of aminodienones to pyridines using N-iodosuccinimide.
机构信息
School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
出版信息
Molecules. 2010 Apr 30;15(5):3211-27. doi: 10.3390/molecules15053211.
Abstract
Cyclodehydration of Bohlmann-Rahtz aminodienone intermediates using N-iodosuccinimide as a Lewis acid proceeds at low temperature under very mild conditions to give the corresponding 2,3,6-trisubstituted pyridines in high yield and with total regiocontrol.
摘要
Bohlmann-Rahtz 氨二烯酮中间体的环脱水反应在低温下，使用 N-碘代丁二酰亚胺作为路易斯酸，在非常温和的条件下进行，以高产率和完全区域控制得到相应的 2,3,6-三取代吡啶。
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