Sahlstedt Leila, von Bonsdorff Leni, Ebeling Freja, Parkkinen Jaakko, Juvonen Eeva, Ruutu Tapani
Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Eur J Haematol. 2009 Nov;83(5):455-9. doi: 10.1111/j.1600-0609.2009.01310.x. Epub 2009 Jul 1.
Free iron induced hydroxyl radical formation is one possible mechanism for tissue injury during cytotoxic therapy. We studied the appearance of free, non-transferrin-bound iron (NTBI) at baseline and during the 20-d period after the onset of cytotoxic chemotherapy in patients with haematological malignancy undergoing intensive chemotherapy or conditioning for autologous stem cell transplantation (aSCT). NTBI was detected on average for 15.6 d in patients treated with chemotherapy only, and for 6.1 d in patients undergoing aSCT. The recovery of the bone marrow function coincided with the disappearance of NTBI. The type of the conditioning regimen was also associated with the appearance of NTBI. The timing of the presence of NTBI accords with the presence of the most important non-infectious complication of intensive chemotherapy and autologous transplantation, mucosal injury, and free iron is likely to contribute to this and probably other complications of the intensive treatments.
游离铁诱导的羟基自由基形成是细胞毒性治疗期间组织损伤的一种可能机制。我们研究了血液系统恶性肿瘤患者在接受强化化疗或自体干细胞移植（aSCT）预处理时，基线及细胞毒性化疗开始后20天内游离的、非转铁蛋白结合铁（NTBI）的出现情况。仅接受化疗的患者中NTBI平均检测到15.6天，接受aSCT的患者中为6.1天。骨髓功能的恢复与NTBI的消失同时发生。预处理方案的类型也与NTBI的出现有关。NTBI出现的时间与强化化疗和自体移植最重要的非感染性并发症——黏膜损伤的出现时间一致，游离铁可能导致这种情况以及强化治疗的其他并发症。
