Sleep Research Unit, Dept of Physiology, University of Turku, Lemminkäisenkatu 14-18 A, FI-20014, Turku, Finland.
Eur Respir J. 2009 Nov;34(5):1132-9. doi: 10.1183/09031936.00017909. Epub 2009 Jul 2.
The risks of metabolic syndrome and sleep-disordered breathing increase around the time of the menopause. We have previously shown that features of the nocturnal transcutaneous carbon dioxide (TcCO2) profile are associated with metabolic variables such as cholesterol, glycosylated haemoglobin A1C (GHbA1C) and blood pressure in patients with sleep apnoea. In the present study, we investigated whether these metabolic variables can be predicted using noninvasive TcCO2 measurements during sleep in generally healthy post-menopausal females. 22 post-menopausal females underwent an overnight polygraphic sleep study that involved the continuous monitoring of arterial oxygen saturation (S(a,O2)) and TcCO2. Body composition, GHbA1C, plasma cholesterol and blood pressure were measured prior to the sleep study. Nocturnal TcCO2 features were the most important predictors of lipoprotein cholesterols, triglycerides and blood pressure levels. A longer sleep period and higher TcCO2 levels were linked with lower GHbA1C, and fragmented sleep with lower high-density lipoprotein cholesterol. Neither nocturnal S(a,O2) indices nor the apnoea/hypopnoea index had a predictive power. The results suggest that nocturnal TcCO2 events revealed metabolic risk factors already present in healthy post-menopausal females.
代谢综合征和睡眠呼吸紊乱的风险在更年期前后增加。我们之前已经表明，睡眠呼吸暂停患者的夜间经皮二氧化碳（TcCO2）曲线特征与胆固醇、糖化血红蛋白 A1C（GHbA1C）和血压等代谢变量有关。在本研究中，我们研究了这些代谢变量是否可以通过睡眠期间无创 TcCO2 测量来预测一般健康的绝经后女性。22 名绝经后女性接受了一整夜的多导睡眠研究，包括连续监测动脉血氧饱和度（S(a,O2)）和 TcCO2。在睡眠研究之前测量了身体成分、GHbA1C、血浆胆固醇和血压。夜间 TcCO2 特征是脂蛋白胆固醇、甘油三酯和血压水平的最重要预测因子。较长的睡眠时间和较高的 TcCO2 水平与较低的 GHbA1C 相关，而睡眠片段化与较低的高密度脂蛋白胆固醇相关。夜间 S(a,O2)指数和呼吸暂停/低通气指数均没有预测能力。研究结果表明，夜间 TcCO2 事件揭示了健康绝经后女性已经存在的代谢风险因素。
