Zheng Yan-Fen, Chen Zuo-Liang, Chen Hong-Bo, Cheng Jun
Department of Oral Medicine, Xiamen Dental Hospital, School of Stomatology, Fujian Medical University, Xiamen Fujian, 361003, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2009 Mar;44(3):168-71.
To investigate the expression of survivin during oral carcinogenesis and its relationship with the expression of Bcl-2 and p53.
Two-step immunohistochemical method was employed to detect the expression of survivin, Bcl-2 and p53 in 60 rat tongue carcinogenesis specimens induced by 4-nitro-quinoline 1-oxide (4NQO).
Survivin was present in 1/36 cases of normal mucosa, 6/11 cases of oral epithelial dysplasia and 10/11 cases of oral carcinoma. There were significant difference in the expression of survivin among normal mucosa, oral epithelial dysplasia and carcinoma (P < 0.001). While in the 17 cases of positive expression of survivin, Bcl-2 was present in 12 cases and p53 was present in 8 cases. The expression of survivin in oral epithelial dysplasia and carcinoma were significantly higher than that in normal oral mucosa (P < 0.01). The expression of survivin was positively correlated to the expression of Bcl-2 and p53 in rat tongue (P < 0.01).
The expression of survivin may play an important role in oral carcinogenesis. Survivin, Bcl-2 and p53 may be synergetic in the carcinogenesis of oral cancer.
研究生存素在口腔癌发生过程中的表达及其与Bcl-2和p53表达的关系。
采用两步免疫组化法检测60例4-硝基喹啉-1-氧化物（4NQO）诱导的大鼠舌癌发生标本中生存素、Bcl-2和p53的表达。
生存素在1/36例正常黏膜、6/11例口腔上皮发育异常和10/11例口腔癌中表达。正常黏膜、口腔上皮发育异常和癌组织中生存素的表达有显著差异（P < 0.001）。在17例生存素阳性表达病例中，Bcl-2在12例中表达，p53在8例中表达。口腔上皮发育异常和癌组织中生存素的表达明显高于正常口腔黏膜（P < 0.01）。大鼠舌组织中生存素的表达与Bcl-2和p53的表达呈正相关（P < 0.01）。
生存素的表达可能在口腔癌发生中起重要作用。生存素、Bcl-2和p53在口腔癌发生过程中可能协同作用。
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