Guner Yigit S, Elliott Steven, Marr Clifford C, Greenholz Stephen K
Department of General Surgery, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Pediatr Surg Int. 2009 Aug;25(8):715-8. doi: 10.1007/s00383-009-2411-1. Epub 2009 Jul 4.
The loss of normal anatomic barriers in neonates with congenital diaphragmatic hernia (CDH) can predispose children to gastroesophageal reflux (GER). In an attempt to improve post-operative feeding, we have added a modified anterior fundoplication to restore natural gastric and esophageal positioning.
The institutional review board of both participating centers approved this study. Between 1997 and 2008, 13 neonates with high-risk anatomy underwent repair of CDH combined with an anterior fundoplication (Boix-Ochoa). The anatomic indications for concomitant fundoplication were absence of an intra-abdominal esophagus, an obtuse angle of His, and a small, vertically oriented stomach.
Ten patients survived to discharge and eight were on full oral nourishment. One required partial gastrostomy feedings for an improving oral aversion and quickly progressed to full oral feedings. One patient with chromosomal anomalies and swallowing dysfunction remained on long-term bolus gastrostomy feedings. Two with progressive symptoms of GER and failure to thrive required conversion to a 360 degrees wrap after 18 months of medical management. This was performed in conjunction with a planned, staged muscle flap reconstruction in one patient. There were no complications related to the fundoplication.
Anatomic predictors of severe GER can be efficiently countered at the time of CDH repair. A modified fundoplication should be considered in the operative management of high-risk infants.
先天性膈疝(CDH)新生儿正常解剖屏障的丧失会使儿童易患胃食管反流(GER)。为了改善术后喂养,我们增加了改良的前胃底折叠术以恢复胃和食管的自然位置。
两个参与中心的机构审查委员会批准了本研究。1997年至2008年间,13例具有高危解剖结构的新生儿接受了CDH修复术并联合前胃底折叠术(Boix-Ochoa术)。同时进行胃底折叠术的解剖学指征为腹腔内食管缺失、His角钝以及胃小且垂直。
10例患者存活至出院,8例完全经口喂养。1例因逐渐出现的口腔厌恶需要部分胃造瘘喂养,随后很快进展为完全经口喂养。1例患有染色体异常和吞咽功能障碍的患者仍长期接受推注式胃造瘘喂养。2例有进行性GER症状且生长发育不良的患者在接受18个月的药物治疗后需要改为360度包绕术。其中1例患者同时进行了计划性分期肌瓣重建术。没有与胃底折叠术相关的并发症。
在CDH修复时可有效应对严重GER的解剖学预测因素。对于高危婴儿的手术治疗应考虑改良胃底折叠术。