Zubcov A A, Fendick M G, Gottlob I, Wizov S S, Reinecke R D
Wills Eye Hospital, Philadelphia, PA 19107.
Am J Ophthalmol. 1991 Dec 15;112(6):714-22.
It is debatable whether chiasmatic misrouting of temporal optic-nerve fibers (similar to that found in ocular albinism) is also characteristic of dissociated vertical deviation. Pattern appearance, pattern reversal, and diffuse-flash, monocular full-field visual-evoked cortical potentials were recorded from albino and normal human subjects and subjects with dissociated vertical deviation. Pattern appearance was the most reliable stimulus for evaluating lateralization (albino-type misrouting) in adult albino patients, and diffuse-flash stimulation was almost as reliable in children. Pattern reversal was found to be an unreliable indicator. Lateralization was not evident among patients with dissociated vertical deviation, as determined by the three modes of stimulation. Our data supported earlier findings that pattern appearance is the most appropriate technique to detect lateralization. Our findings differed from those of previous reports in demonstrating that reliability of the lateralization phenomenon increases with age up to approximately 15 years. Pattern reversal stimulation was not reliable in patients with horizontal nystagmus.
颞侧视神经纤维的交叉错路（类似于眼白化病中所见）是否也是分离性垂直偏斜的特征，这一点存在争议。对白化病患者、正常人类受试者以及分离性垂直偏斜患者记录了图形出现、图形反转和弥散闪光单眼全视野视觉诱发皮层电位。图形出现是评估成年白化病患者偏侧化（白化病型错路）最可靠的刺激方式，而弥散闪光刺激在儿童中几乎同样可靠。图形反转被发现是一个不可靠的指标。通过三种刺激模式确定，分离性垂直偏斜患者中未发现偏侧化现象。我们的数据支持了早期的研究结果，即图形出现是检测偏侧化最合适的技术。我们的研究结果与之前的报告不同，表明偏侧化现象的可靠性随年龄增长至约15岁而增加。图形反转刺激在水平性眼球震颤患者中不可靠。
