Sakuta R, Aikawa H, Takashima S, Ryo S
Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
Brain Dev. 1991 Jul;13(4):260-5. doi: 10.1016/s0387-7604(12)80060-x.
A neuropathologic examination of a 5-year-boy with epidermal nevus syndrome and hemimegalencephaly revealed 1) left hemimegalencephaly with an increased volume of the white matter, and 2) cerebral polymicrogyria with pachygyria, heterotopic neurons and prominent astrogliosis. Golgi staining revealed hypertrophic neurons with increased dendrites and spines. The hemihypertrophy of the cerebral hemispheres seems to have contributed to an increased volume of the white matter with migration disorder, and may have been due to a disorder in the germinal cell proliferation stage.
对一名患有表皮痣综合征和半侧巨脑症的5岁男孩进行的神经病理学检查显示：1）左侧半侧巨脑症，白质体积增加；2）脑回肥厚伴多小脑回、神经元异位和明显的星形胶质细胞增生。高尔基染色显示神经元肥大，树突和棘突增加。大脑半球的半侧肥大似乎导致了白质体积增加并伴有迁移障碍，这可能是由于生发细胞增殖阶段的紊乱所致。
