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[淀粉及其衍生物在口服和注射用药物剂型技术中作为辅料的应用]

[Starch and its derivatives as excipients in oral and parenteral drug form technology].

作者信息

Zgoda Marian Mikołaj, Kolodziejczyk Michał Krzysztof, Nachajski Michał Jakub

机构信息

Zakład Technologii Postaci Leku, Katedra Farmacji Stosowanej, Uniwersytetu Medycznego w Lodzi.

出版信息

Polim Med. 2009;39(1):31-45.

Abstract

The morphological and structural properties of basic types of starch used as excipients in solid drug form technology with reference to its bioadhesive properties with fully polymer biodegradation. The production technology and application of: carboxymethyl starch (CMS), pregelled starch, hydroxyethyl starch (HES), hydroxypropyl starch (HPS) and the share of modified starch in technology of selected food products is provided. The authors focus on hydroxyethyl starch, which is used not only as blood and plasma substitution but also as drug camouflage agent in sports competition. In papers were presented based on literature data actually used types of starch and their chemical modifications products in drug forms and food technology.

摘要

用作固体药物剂型技术辅料的基本淀粉类型的形态和结构特性,及其具有完全聚合物生物降解性的生物粘附特性。介绍了羧甲基淀粉(CMS)、预胶化淀粉、羟乙基淀粉(HES)、羟丙基淀粉(HPS)的生产技术和应用,以及改性淀粉在特定食品中的应用比例。作者重点关注羟乙基淀粉,其不仅用作血液和血浆替代品,还用作体育比赛中的药物伪装剂。论文基于文献数据,介绍了药物剂型和食品技术中实际使用的淀粉类型及其化学改性产物。

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