烷基甲基酮与β-硅亚甲基丙二酸酯的高度区域和对映选择性有机催化共轭加成反应。
Highly regio- and enantioselective organocatalytic conjugate addition of alkyl methyl ketones to a beta-silylmethylene malonate.
作者信息
Chowdhury Raghunath, Ghosh Sunil K
机构信息
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
出版信息
Org Lett. 2009 Aug 6;11(15):3270-3. doi: 10.1021/ol900803n.
PMID:19580247
Abstract
(S)-N-(2-pyrrolidinylmethyl)pyrrolidine/trifluoroacetic acid (3:1) combination catalyzed the direct addition of alkyl methyl ketones to beta-dimethyl(phenyl)silylmethylene malonate at the methyl terminal with high yield and excellent regio- and enantioselectivity. The silyl group played crucial roles in regioselection and substrate reactivity.
摘要
（S）-N-（2-吡咯烷基甲基）吡咯烷/三氟乙酸（3:1）组合催化烷基甲基酮在甲基端直接加成到β-二甲基（苯基）硅基亚甲基丙二酸酯上，产率高，区域选择性和对映选择性优异。硅基在区域选择性和底物反应性中起关键作用。
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