水相兼容的亚铵离子活化：丙二酸酯与α,β-不饱和烯酮的高对映选择性的有机催化迈克尔加成反应。
Water-compatible iminium activation: highly enantioselective organocatalytic Michael addition of malonates to α,β-unsaturated enones.
机构信息
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000 China.
出版信息
J Org Chem. 2010 Nov 5;75(21):7428-30. doi: 10.1021/jo101188m.
PMID:20936828
Abstract
The highly enantioselective Michael addition of malonates to α,β-unsaturated ketones in water was reported to be catalyzed by a primary-secondary diamine catalyst containing a long alkyl chain. This asymmetric Michael addition process was found to be effective for a variety of α,β-unsaturated ketones.
摘要
含有长烷基链的伯仲二胺催化剂可以高效地催化丙二酸酯与α,β-不饱和酮的高度对映选择性迈克尔加成反应。该不对称迈克尔加成过程对于多种α,β-不饱和酮都具有很好的效果。
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