妊娠及产后慢性髓性白血病女性患者的治疗反应

Response to treatment in women with chronic myeloid leukemia during pregnancy and after delivery.

作者信息

Klamová Hana, Marková Markéta, Moravcová Jana, Sisková Magda, Cetkovský Petr, Machová Poláková Katerina

机构信息

Institue of Hematology and Blood Transfusion, U Nemocnice 1, 12820 Prague, Czech Republic.

出版信息

Leuk Res. 2009 Nov;33(11):1567-9. doi: 10.1016/j.leukres.2009.05.012. Epub 2009 Jul 5.

DOI:10.1016/j.leukres.2009.05.012

PMID:19580997

Abstract

Here we report response to treatment of chronic myeloid leukemia (CML) of five pregnant women during and after pregnancy. CML was diagnosed during pregnancy in three patients. Pregnancy was confirmed during CML in two patients: in one in the 21st week of pregnancy while on imatinib, in another in the 12th week during the interferon treatment. Interferon with leukapheresis when needed was applied in the 2nd and 3rd trimester. All patients except one achieved complete hematological response during pregnancy. After delivery four patients achieved partial cytogenetic response on imatinib and two patients achieved major molecular response after crossover to dasatinib.

摘要

在此，我们报告了5名孕妇在孕期及产后慢性髓性白血病（CML）的治疗反应。3例患者在孕期被诊断为CML。2例患者在CML病程中确诊妊娠：1例在妊娠21周时正在服用伊马替尼，另1例在干扰素治疗期间于妊娠12周时确诊。在孕中期和孕晚期，根据需要应用干扰素并进行白细胞去除术。除1例患者外，所有患者在孕期均达到完全血液学缓解。分娩后，4例患者服用伊马替尼后达到部分细胞遗传学缓解，2例患者换用达沙替尼后达到主要分子学缓解。