Morlan Gracia L, Balseiro Gómez J, Gil-Nagel Rein A, González Guerrero J L, Martínez Martín P
Sección de Neurología, Hospital Central de la Cruz Roja Española San José y Santa Adela, Madrid.
Arch Neurobiol (Madr). 1991 Jul-Aug;54(4):135-9.
We studied the etiology of seizures in 46 patients who developed seizures after age 65 years. The most frequent cause was cerebrovascular disease, accounting for 41.3% of all cases. Clinical diagnosis of Alzheimer's disease was made in 5 patients (10.8%). Other etiologies were; metabolic encephalopathies in 6.5%, craniocerebral trauma in 4.3% and glioma in 2.1%. The etiology of seizures remained unknown in 34.7%. They had generalized tonic-clonic seizures in 48%. They were partial or partial secondarily generalized in 44.1%. The role of Alzheimer's disease in late onset seizures has not been important enough in previous studies. We believe that a well-designed prospective study will let us know the real frequency of the causes of seizures in the elderly.
我们研究了46例65岁以后发生癫痫的患者的癫痫病因。最常见的病因是脑血管疾病，占所有病例的41.3%。5例（10.8%）患者临床诊断为阿尔茨海默病。其他病因包括：代谢性脑病占6.5%，颅脑外伤占4.3%，胶质瘤占2.1%。34.7%的癫痫病因仍不明。48%的患者发生全面性强直阵挛发作。44.1%的患者为部分性发作或部分性继发全面性发作。在以往研究中，阿尔茨海默病在晚发性癫痫中的作用尚不十分重要。我们认为，一项精心设计的前瞻性研究将使我们了解老年人癫痫病因的实际发生率。
