联合降脂治疗时出现意外且异常低的高密度脂蛋白胆固醇水平。
Unexpected and abnormally low HDL cholesterol levels on combination hypolipidemic therapy.
作者信息
Unnikrishnan R, Das R, Jaydip R, Sudhakaran C, Mohan V
机构信息
Dr. Mohan's Diabetes Specialities Centre, & Madras Diabetes Research Foundation, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, Chennai.
出版信息
J Assoc Physicians India. 2009 Feb;57:180-1.
In general, Indians have low HDL cholesterol levels. Fenofibrate, a drug widely used in the treatment of hypertriglyceridemia, usually also increases HDL cholesterol. There have been a few reports in the literature of a paradoxical decrease in serum HDL-cholesterol in patients treated with fenofibrate, either alone or in combination with a statin. We report three cases of paradoxical decrease in serum HDL-cholesterol in type 2 diabetic patients treated with a statin-fenofibrate combination.
一般来说，印度人的高密度脂蛋白胆固醇水平较低。非诺贝特是一种广泛用于治疗高甘油三酯血症的药物，通常也会增加高密度脂蛋白胆固醇。文献中已有几篇报道指出，单独使用或与他汀类药物联合使用非诺贝特治疗的患者，血清高密度脂蛋白胆固醇会出现反常降低的情况。我们报告了3例使用他汀类药物 - 非诺贝特联合治疗的2型糖尿病患者血清高密度脂蛋白胆固醇反常降低的病例。
Zotero 插件