通过分子动力学模拟对兔朊病毒结构稳定性的研究。
Studies on the structural stability of rabbit prion probed by molecular dynamics simulations.
作者信息
Zhang Jiapu
机构信息
Centre for Informatics and Applied Optimization, School of ITMS, The University of Ballarat, 15/172 Princes St, Carlton North VIC 3054, Australia.
出版信息
J Biomol Struct Dyn. 2009 Oct;27(2):159-62. doi: 10.1080/07391102.2009.10507305.
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect humans and animals. Rabbits are the only mammalian species reported to be resistant to infection from prion diseases isolated from other species (I. Vorberg et al., Journal of Virology 77 (3), 2003-2009 (2003)). At the end of 2007 the NMR structure of rabbit prion (124-228) was deposited into protein data bank (PDB entry 2FJ3). This paper studies the inhibition mechanism of rabbit prion at molecular structural level by molecular dynamics simulations.
朊病毒疾病是一类不可避免地会导致死亡且具有高度传染性的神经退行性疾病，可影响人类和动物。兔子是唯一被报道对源自其他物种的朊病毒疾病感染具有抗性的哺乳动物物种（I. 沃尔伯格等人，《病毒学杂志》77 (3)，2003 - 2009 (2003)）。2007年底，兔朊病毒（124 - 228）的核磁共振结构被存入蛋白质数据库（PDB条目2FJ3）。本文通过分子动力学模拟在分子结构水平上研究兔朊病毒的抑制机制。
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